Regulation of neurotransmitter release and synaptic vesicle recycling by protein ubiquitination

2014 Seed Grant
Clarissa Waites, Ph.D.
Department of Neuroscience
Columbia University

This proposal seeks to understand how an important protein modification called ‘ubiquitination’ regulates signaling in the brain. Defects in ubiquitination are linked to multiple neurodegenerative and neuropsychiatric disorders (e.g. autism, schizophrenia, Parkinson’s disease). However, very little is known about how ubiquitination contributes to normal brain function, or how defective ubiquitination disrupts communication between neurons and leads to impaired cognition and behavior. Our proposed studies will shed light on these questions. This work will also identify potential therapeutic targets for treating diseases that arise from dysregulated ubiquitination.

Other Grants

Lindsay M. De Biase, Ph.D., University of California Los Angeles
The Role of Microglial Lysosomes in Selective Neuronal Vulnerability
Synapses, the sites of signaling between neurons in the brain, play essential roles in learning, memory, and the health of neurons themselves. An enduring mystery is why some neurons are…
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As animals navigate their environments, they construct internal models of the external sensory world and use these models to guide their behavior. This ability to incorporate ongoing sensory stimuli into…
Xiaojing Gao, Ph.D., Stanford University
When Neural Circuits Meet Molecular Circuits: Quantitative Genetic Manipulation with Single-cell Consistency
Cells are the building blocks of our bodies. We get sick when the cells “misbehave”. The way modern gene therapies work is to introduce genes, fragments of DNA molecules that…
Rafiq Huda, Ph.D., Rutgers University
Conducting the Orchestra of Movement—Functional Role of Striatal Astrocytes in Health and Disease
Movement requires coordinated activity across a large brain-wide network. The striatum is a particularly important part of this circuit; it integrates motor-related information from many distinct brain regions to regulate…