The largest organ of the brain is the cerebral cortex, a sheet of tissue that is divided up into areas. Cortical areas are modules responsible different functions, like vision, hearing and memory. Areas in turn contain smaller modules called columns. The different columns within each area are specialized to carry out different tasks. For example, in the primary visual area, VI, there are columns for the left eye and columns for the right eye. The structure of the columns can be changed by experience. In young animals, for example, depriving VI of vision from one eye by closing an eyelid will alter the size of the columns. The columns themselves are, however, initially established very early in development, before the onset of visual sensory experience, and despite the importance of columns for brain function, the molecules involved in making columns are completely unknown. Dr. Ragsdale proposes that an evolutionarily conserved set of signaling molecules, ones known to be responsible for making the limbs, the teeth, the face and even the areas of the cerebral cortex, are likely to be redeployed again at a later stage in embryonic development to make the columns of the cortex. In the planned work, Dr. Ragsdale’s group will isolate by molecular cloning specific markers for these developmental signaling systems and ask whether these molecules are, as predicted, involved in the development of the columns of the cortex.
Columns are a key structural feature of the cerebral cortex, and likely essential for much of cortical function in humans. For example, when an eye is deflected in a young experimental animal to create a model for strabismus, there are irreversible changes in the columns of the part of cortex responsible for vision. When these deflection is carried out in older animals, however, the columnar organization of the cortex does not change. A similar time course for visual system plasticity is seen in human development. Amblyopia (“lazy eye”), for example, responds best to intervention before 6 years of age. It is widely thought that these limits on visual system plasticity in humans are due to the limits on cortical column plasticity. Moreover, it seems likely that cortical columns and their development are important for much of the cerebral cortex. Molecular information about how cortical columns are initially generated in the embryo is therefore likely to provide broad insight into developmental disorders of brain development.

Other Grants

Sarah C. Goetz, Ph.D., Duke University
Uncovering a Novel Role for Primary Cilia in Eph/Ephrin Signaling in Neurons
2022 Seed GrantSarah C. Goetz, Ph.D. Duke University Women’s Council Seed Grant Primary cilia are tiny projections from cells that function like an antenna- they receive and may also send…
Erin M. Gibson, Ph.D., Stanford University
Circadian Regulation of Oligodendroglial Senescence and Metabolomics in Aging
2022 Seed GrantErin M. Gibson, Ph.D.Stanford University The brain consists of two main classes of cells, neurons and glia. Glia make-up more than half of the cells in the brain…
Yvette Fisher, Ph.D., University of California, Berkeley
Dynamic Modulation of Synaptic Plasticity During Spatial Exploration
2022 Seed GrantYvette Fisher, Ph.D.University of California, Berkeley The Virginia (Ginny) & Roger Carlson Seed Grant Cognitive flexibility is critical for appropriately adjusting thoughts and behaviors to meet changing demands…
Byoung Il Bae, Ph.D., University of Connecticut
Unique Vulnerability of Developing Human Cerebral Cortex to Loss of Centrosomal Protein
2022 Seed GrantByoung Il Bae, Ph.D.University of Connecticut Carl & Marilynn Thoma Foundation Seed Grant The cerebral cortex is the largest and outermost part of the human brain. It is…