Archives: Grants

Rebekah C. Evans, Ph.D., Georgetown University

In Vivo and Ex Vivo Dissection of Midbrain Neuron Activity During Exercise

Exercise is important for the health of the body and the mind. Exercise promotes learning and reduces symptoms of brain-related diseases such as Parkinson’s disease and Alzheimer’s disease. However, it is not known how exercise changes the brain to enhance function. Previous studies h...

William J. Giardino, Ph.D. Stanford University

Deciphering the Neuropeptide Circuitry of Emotional Arousal in Narcolepsy

This research project aims to investigate the neural mechanisms of a specific type of brain cell called neuropeptide neurons within a region of the brain’s amygdala network called the bed nucleus of the stria terminalis (BNST). Dr. Giardino’s proposal pursues the possibility that thes...

Howard Gritton, Ph.D., University of Illinois

Attention Mechanisms Contributing to Auditory Spatial Processing.

Our world is composed of a rich mixture of sounds. We often process sounds including speech in the presence of many other competing auditory stimuli (e.g., voices in a crowded room, music, etc.). The problem of understanding speech in these difficult conditions is referred to as the “cockta...

Nora Kory, Ph.D., Harvard University

Elucidating the Fates and Functions of Lactate in the Brain

The human brain requires significant energy to function. Despite accounting for only 2% of our body weight, the brain consumes a substantial 20% of the body’s energy, relying on a continuous supply of fuel from the bloodstream. Glucose serves as the brain’s primary energy source, unde...

Hojoon Lee, Ph.D., Northwestern University

Deciphering the Neural Circuitry of Nausea

How does the body tell the brain that something is just not right? Nausea is an unpleasant sensation that has likely evolved as a general defense mechanism to signal and remedy physiological distress. Nausea (often accompanied by dizziness, vomiting, and cold sweats) has been recognized since cla...

Eirene Markenscoff-Papadimitriou, Ph.D., Cornell University

Neuronal Vulnerability to Heterochromatin Dysregulation in Development

Autism affects more than 2% of 8-year-olds in the United States, and we do not understand what the causes are. Many individuals with autism have a mutation in their DNA that affects a gene called SUV420H1. This gene controls how DNA is packaged within the nucleus of the cell. However, this gene&r...

Bridget Ostrem, M.D., Ph.D. University of California San Francisco

Investigating the Therapeutic Potential of Human Milk Oligosaccharides

Premature birth, defined as birth before 37 weeks of completed gestation, is associated with many medical complications. Preterm white matter injury is the most common cause of brain injury in premature infants, affecting approximately 500,000 babies worldwide each year. This condition has no cur...

Benjamin Scholl, Ph.D. University of Pennsylvania

Elucidating Synapse Dysfunction Using In Vivo Single-Cell CRISPR/Cas9 Manipulations

Synapses are an elementary until of brain circuits. Synapses allow neurons to communicate to one another and for information to be processed by circuits. In many neurodevelopmental disorders, such as autism spectrum disorder and Fragile X Syndrome, synapses are altered. However, it is unclear how...

Natale R. Sciolino, Ph.D. University of Connecticut

Impact of Locus Coeruleus Dynamics on Gustatory Cortex Function

Neurons in the locus coeruleus (LC) that release the neuromodulator norepinephrine can alter the brain’s response to sensory information, but their impact on taste has never been explored. The overarching goal of Dr. Sciolino’s research is to understand the influence of LC neurons on ...

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