Everything You Need to Know About Depression

Depression is a common but serious mental health disorder that affects how people feel, think, and behave. It goes beyond temporary sadness, influencing daily life and well-being in profound ways. Understanding depression is essential, as it affects millions worldwide and is treatable with the right interventions.

What is Depression?

Depression, clinically known as Major Depressive Disorder (MDD), is characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities once enjoyed. It can interfere with personal relationships, work, and even physical health if left untreated.

Signs and Symptoms

Emotional symptoms

  • Prolonged sadness or emptiness
  • Loss of interest in hobbies or activities
  • Feelings of guilt, worthlessness, or helplessness
  • Irritability or frustration

Physical symptoms

  • Fatigue or lack of energy
  • Changes in appetite or weight (increase or decrease)
  • Sleep disturbances (insomnia or oversleeping)
  • Unexplained aches or pains

Cognitive symptoms

  • Difficulty concentrating, making decisions, or remembering
  • Thoughts of death, self-harm, or suicide

What Causes Depression?

Depression arises from a combination of biological, psychological, and social factors. Some key contributors include:

  • Genetics: A family history of depression increases risk.
  • Brain chemistry: Imbalances in neurotransmitters like serotonin and dopamine affect mood.
  • Life events: Traumatic events, such as loss, abuse, or financial stress, can trigger depressive episodes.
  • Chronic illness: Conditions like diabetes, cancer, or chronic pain can contribute to depression.

Types of Depression

  • Major Depressive Disorder: Persistent, severe symptoms lasting at least two weeks.
  • Persistent Depressive Disorder (Dysthymia): Milder, long-term symptoms lasting for two years or more.
  • Postpartum Depression: Occurs after childbirth due to hormonal changes.
  • Seasonal Affective Disorder (SAD): Triggered by seasonal changes, often in winter months.

Treatment and Management

Effective treatments are available and vary depending on the severity of depression.

Therapy

  • Cognitive Behavioral Therapy (CBT): Helps patients reframe negative thoughts.
  • Interpersonal Therapy (IPT): Focuses on improving relationships and communication.

Medications

  • Antidepressants, such as SSRIs and SNRIs, help regulate mood by balancing brain chemicals.
  • Always follow a healthcare provider’s guidance when starting or stopping medication.

Lifestyle Changes

  • Regular exercise boosts endorphins and improves mood.
  • Eating a balanced diet supports brain health.
  • Maintaining sleep hygiene is essential for emotional stability.

Support Networks

  • Talking to family, friends, or support groups can provide comfort and understanding.
  • In severe cases, hospitalization or intensive outpatient care may be required.

When to Seek Help

If symptoms last for more than two weeks or interfere with daily functioning, professional help is recommended. If someone is experiencing suicidal thoughts, seek emergency care immediately. Remember, depression is treatable, and seeking help is a sign of strength, not weakness.

Important Takeaways

Depression is a serious but manageable condition. Early intervention, professional care, and supportive networks play vital roles in recovery. Raising awareness and reducing stigma surrounding mental health is crucial to ensuring individuals feel comfortable seeking the help they need. You are not alone—help is available, and recovery is possible.

Our Successes

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Aimee Kao, M.D., Ph.D.
BRF Accelerates a Lab and Career
Dr. Aimee Kao generates human cell lines to model neurodegenerative disorders The BRF Seed Grant was crucial in establishing us as a lab that is leading the work on neuroregeneration…
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Ravi Allada, M.D.
Sleep Disorders and Neurodegenerative Diseases
Ravi Allada, M.D., Professor of Neurobiology at Northwestern University, is interested in the molecular mechanisms underlying circadian rhythms and their links to various clinical disorders, including insomnia, depression and even…
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Dr. Krishnan, Ph.D.
High Impact
“The BRF Scientific Innovations Award allowed us to do bold, transformative work for which there was no precedent. I am grateful that BRF takes risks on innovation.”
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Dr. Nicholas Hatsopoulos
From the Lab to the Patient
In 2002 Dr. Nicholas Hatsopoulos, Department of Organismal Biology and Anatomy at The University of Chicago, was awarded his first $25,000 seed grant. His lab set out to understand the…

Our Grants

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José Manuel Baizabal Carballo, Ph.D., Indiana University Bloomington
Heterochromatin Mechanisms of Cortical Expansion
Neurodevelopmental disorders, such as autism and schizophrenia, are frequently associated with mutations in genes that encode chromatin-modifying enzymes. A subset of these mutations is thought to disrupt compacted chromatin (heterochromatin),…
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Jessica L. Bolton, Ph.D., Georgia State University
Chemogenetic Tools in Microglia as a Novel Therapeutic Approach for Brain Disorders
All humans are born with a unique combination of genes, which contribute greatly to who we are. However, early-life experiences such as trauma or hardship, particularly during the first few…
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Junyue Cao, Ph.D., The Rockefeller University
Elucidate the Molecular and Cellular Targets of Caloric Restriction in Rejuvenating Aged Mammalian Brain
As we age, the brain’s ability to function declines, increasing the risk of cognitive impairments and neurological diseases like Alzheimer’s and Parkinson’s. Our research investigates how caloric restriction (CR), a…
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Vasileios Christopoulos, Ph.D., University of Southern California
Understanding the Mechanisms of Micturition in the Brain and Spinal Cord
This research aims to better understand how the brain and spinal cord work together to control urination, a process known as micturition. In healthy individuals, this process is carefully coordinated…

Innovation Awards

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Robert Froemke Ph.D., NYU School of Medicine
The Neuroscience of Families: Social Behavior in Naturalistic Controlled Environments
Animals can work together in groups to achieve specific aims with higher success rates than if acting alone. For communally-living and consociating species such as humans and rodents, group dynamics…
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Ken Prehoda, Ph.D., University of Oregon
Brain Regeneration Dynamics Using the Transparent Fish Danionella Cerebrum
Regenerative medicine may one day enable us to repair brain damage caused by injury and disease. While humans and other mammals cannot regenerate the central nervous system, fish have an…
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Doris Tsao, Ph.D., University of California, Berkeley
Understanding how psychedelics affect top-down belief propagation in the primate brain
Our research will try to understand how special substances called psychedelics can help the brain see the world differently. When people are sad or worried, their brains sometimes get “stuck”…
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James J DiCarlo, M.D., Ph.D., Massachusetts Institute of Technology
Using Computer Models of the Neural Mechanisms of Visual Processing to Non-Invasively Modulate Brain States
DiCarlo’s research team is exploring an innovative approach to address emotional challenges, such as anxiety and depression. Traditional treatments for these disorders can be complex and often cause unpleasant side effects,…

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