Archives: Awards

Shigeki Watanabe, Ph.D., Johns Hopkins University

Intrinsic and Extrinsic Mechanisms Underlying Synaptic Proteostasis

Waste management and sustainability are major challenges humans face in the 21st-century. As you concentrate and think about these issues, nerve cells in your brain must deal with the exact same problem—how do they manage their trash? Unlike other cells in our body, most nurse cells must la...

Ilana Witten, Ph.D. Princeton University

A Role for Dopamine During Rest and Sleep in Memory Consolidation

One of the most fundamental functions of the nervous system is to form memories of salient experiences. What neural mechanisms enables some experience to turn into permanent memories, while the vast majority are forgotten? There is increased appreciation that offline replay of neural activity aft...

Sandeep Robert Datta, M.D., Ph.D., Harvard University

Probing Sensation and Behavior in Autism Spectrum Disorder Models

Autism Spectrum Disorders (ASDs) are characterized by repetitive behaviors and deficits in the core domains of language development and social interactions. While many ASD patients exhibit deficits in sensory processing, the neural basis for these deficits are incompletely understood. Here, Dr. D...

Samuel J. Pleasure, M.D., Ph.D., University of California, San Francisco

Autoantibody Discovery in Neuropsychiatric Disease

The global incidence of schizophrenia is 1 percent and of psychotic syndromes 3.4 percent. The U.S. economic burden of schizophrenia is projected as $16 trillion for 2010-30 including the cost attributable to unemployment. Despite this, over the past three decades the FDA has only approved a sing...

Ryohei Yasuda, Ph.D.

Imaging dynamics of endogenous protein interactions in single dendritic spines

Changes in the efficiency of synaptic communications between neurons underlie learning and memory. This process is called synaptic plasticity and is caused by biochemical reactions mediated by hundreds of species of molecules in each synapse. Many mental diseases are caused by failure of this pro...

James Eberwine, Ph.D.

Single Mitochondrion Analysis and Engineering for Human Neurological Disease

The goal of Dr. Eberwine’s proposal is to enable new therapeutic modalities for treating mitochondrial diseases through the development and use of novel mitochondrial engineering procedures. While mammalian genome engineering has been performed for decades, advances in mitochondria engineer...

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