Archives: Awards

Samuel J. Pleasure, M.D., Ph.D., University of California, San Francisco

Autoantibody Discovery in Neuropsychiatric Disease

The global incidence of schizophrenia is 1 percent and of psychotic syndromes 3.4 percent. The U.S. economic burden of schizophrenia is projected as $16 trillion for 2010-30 including the cost attributable to unemployment. Despite this, over the past three decades the FDA has only approved a sing...

Ryohei Yasuda, Ph.D.

Imaging dynamics of endogenous protein interactions in single dendritic spines

Changes in the efficiency of synaptic communications between neurons underlie learning and memory. This process is called synaptic plasticity and is caused by biochemical reactions mediated by hundreds of species of molecules in each synapse. Many mental diseases are caused by failure of this pro...

James Eberwine, Ph.D.

Single Mitochondrion Analysis and Engineering for Human Neurological Disease

The goal of Dr. Eberwine’s proposal is to enable new therapeutic modalities for treating mitochondrial diseases through the development and use of novel mitochondrial engineering procedures. While mammalian genome engineering has been performed for decades, advances in mitochondria engineer...

Schahram Akbarian, M.D., Ph.D.

Retrospective Neurogenomics in the Mouse

Many genetic factors or environmental exposures impact the immature brain in childhood or early adolescence, but cause psychiatric disease only at much later periods in life. These molecular mechanisms include changes in gene expression and genome function. To date, however, it is not possible to...

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