Archives: Awards

The global incidence of schizophrenia is 1 percent and of psychotic syndromes 3.4 percent. The U.S. economic burden of schizophrenia is projected as $16 trillion for 2010-30 including the cost attributable to unemployment. Despite this, over the past three decades the FDA has only approved a sing...

Among the most intriguing discoveries to emerge from technological advances in recent years are the insights into how the three-dimensional (3D) structure of the genome influences many aspects of local and long-range gene regulation and function. These data suggest that identifying the specific c...

Problems with cognition are the major cause of disability in schizophrenia. One idea is that these result from having too little dopamine in a part of the brain called the prefrontal cortex. Another idea is that abnormalities in a particular class of neurons called parvalbumin interneurons, and t...

Understanding the complex relationships between gene expression, neuronal plasticity, and behavior is a fundamental goal of neuroscience. However the brain contains many types of neurons. Therefore, a systematic understanding of brain function must include an effective strategy for targeting spec...

Brain circuits develop through an interaction between genetics and the environment. Previous studies have shown that there are at least two distinct phases in brain development. During a first genetically determined stage, gene expression dictates the emergence of cell types and their specific co...

The goal of Dr. Eberwine’s proposal is to enable new therapeutic modalities for treating mitochondrial diseases through the development and use of novel mitochondrial engineering procedures. While mammalian genome engineering has been performed for decades, advances in mitochondria engineer...

Many genetic factors or environmental exposures impact the immature brain in childhood or early adolescence, but cause psychiatric disease only at much later periods in life. These molecular mechanisms include changes in gene expression and genome function. To date, however, it is not possible to...

Dr. Biederer’s work focuses on how nerve cells in the brain communicate with each other through cellular connections called synapses. Synapses are formed and remodeled in the maturing and adult…