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Many devastating developmental, neurodegenerative, and acquired central nervous system diseases and injuries primarily affect long-distance connection nerve cells of the cerebral cortex, whose “wiring” of their circuits is performed by extending tiny structures called “growth co...

General anesthesia is a reversible, drug-induced brain state comprised of unconsciousness, amnesia, analgesia and immobility with stability and control of vital physiological systems. Yet the mechanism by which anesthetic drugs induce such brain state remains largely a mystery in neuroscience and...

Brain disorders represent a great societal burden but are among the least understood of all diseases; for psychiatric disorders in particular, the underlying pathologies are largely unknown and treatment is mostly ineffective. Many brain disorders have a genetic component, and advances in genomic...

A longstanding question in neuroscience concerns the cellular mechanisms of learning and memory. Since synapses were first discovered as the sites of communication between neurons, scientists have thought that changes in their number or structure would be a likely substrate of memory. Although ev...

A “burst” is a brief period of high-frequency activity in a neuron, an event that can have a powerful impact on brain circuits. Overly-exuberant bursting—for example, when bursts occur repeatedly…

Dr. Saltzman and his lab propose an innovative and potentially transformative approach for the correction of single-gene disorders of the central nervous system in the fetal brain: in utero administration…

Many neuropsychiatric disorders, including autism and schizophrenia, are thought to arise from disruptions in brain wiring. However, the tools for studying brain wiring are limited in resolution and throughput. Dr.…

The neocortex is the part of our brains that we use for our highest cognitive functions. The main neurons of the neocortex can be lost due to neurodegenerative diseases such…